Vice President, General Manager - TTR

Location: Cambridge
Posted on: June 23, 2025

Job Description:

Why Join Intellia? Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. We wantall ofour people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together. How you will Achieve More at Intellia: This position will be responsible for building, leading and managing the global development and commercialization of the program in order to maximize its future clinical and commercial success. The GM will also serve as the Program Leader and will be responsible for working collaboratively with all functional areas to optimize the overall product opportunity, including time to BLA approval and launch and future commercial uptake thereafter. Summary of Key Responsibilities: Serve as the ultimate point of accountability to lead the global development and commercialization of NTLA-2001 TTR-Amyloidosis Program Establish and drive program vision and strategy, ensuring alignment with corporate objectives across the entire portfolio, including longer-term vision for the company Oversee and lead a team of cross-functional experts across R&D, CMC, Medical Affairs, Access, Commercial, and G&A Responsible for P&L management, ensuring program investment is in line with maximizing commercial success In partnership with Program Management, ensure that appropriate prioritization, adequate resource allocation (money and people), timeline planning and quality checkpoints are met to optimize the program (timeline and deliverables) Integrate information across all aspects of the program to identify, weigh, and balance opportunities and risks, ensuring successful execution of program strategy to both near-term achievement and successful long-term outcomes In partnership with PM, drive alignment of program strategy and execution with Executive Leadership, and Function Heads for key program/corporate decisions Engage all levels of management to escalate and resolve conflicts, remove obstacles, and support the development of program team members The GM will also: Be part of the leadership team at Intellia and report directly to the CEO, with additional accountability to the Executive Leadership Team Serve as a key member of the Development Leadership Team under the CMO to ensure the bridge from Development to Commercial is successful for the program Examples of cross-functional work the GM will lead (not an exhaustive list): Work with Clinical and Med Affairs to launch awareness and patient identification programs globally to boost referral and clinical enrollment Team-up with Regulatory, Clinical Development, Medical Affairs, Access, Commercial and others to develop early-on a unique and competitive BLA filing and registration plan for other countries in line with commercial launch strategy Work with Med Affairs and Commercial to develop intensive patient identification programs and build a centralized information system of commercial leads Partner with Med Affairs, Access, and Commercial to develop an innovative, comprehensive, and competitive Access strategy supported by adequate evidence generation and through external engagements to overcome obstacles, paving a path for efficient delivery of product to patients while ensuring successful reimbursement Develop with Program Management and FP&A, a 5-year strategic and 1-year tactical plan in order to optimize resources (money and people) Manage any strategic alliances related to the program Work closely with Commercial and others to develop market assessment, lay out and plan all pre-launch activities with a focus on defining and targeting the fastest path to a successful launch upon official regulatory approval of marketing application Work closely with Commercial and others to develop a competitive marketing campaign and execute on the global go-to-market strategy About you: Cross-functional program leadership experience with a strong record of accomplishment in biotech or pharma Scientific/advanced degree preferred 15 years progressive Biopharmaceuticals experience, with a background in rare disease development. Direct experience in gene therapy and/or gene-editing a plus Deep knowledge of external landscape, drug development, and path to commercialization Commercial launch experience, including international responsibilities preferred Enterprise mindset with ability to develop and adapt strategy in a complex and evolving landscape Financial acumen with an established track record of budget oversight, accountability, and managing program investment decisions Team leadership, executive presence, and the ability to make things happen Proactive “hands on” individual with collaborative orientation who manages teams effectively, is very self-motivated and can smoothly establish strong working relationships within both internal and external organizations Decisive and collaborative, with ability to guide teams through managing complex scenarios leading to strong recommendations on path forward Excellent interpersonal skills with particular emphasis on communication, influencing, and relationship building (at all levels) Motivated to be part of an organization that aims to make a huge difference through successful launch of new medicines. LI-SV1 Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, are expected to follow all applicable federal, state, and local public health regulations and guidelines, and are strongly encouraged to follow all public health recommendations, including being vaccinated for COVID-19. EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Keywords: , Marthas Vineyard , Vice President, General Manager - TTR, Science, Research & Development , Cambridge, Massachusetts