Sr. Director - Immunology Portfolio Strategy and Operations

Location: Boston
Posted on: June 23, 2025

Job Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Position Summary: The Immunology Research Portfolio Strategy and Operations Lead is responsible for overseeing the strategic and operational execution of the immunology discovery and early clinical portfolio. They will manage portfolio review meetings, ensure alignment with strategic priorities, and coordinate communications with internal and external stakeholders. This role involves optimizing project execution within budget and collaborating with research, clinical leaders, and external innovation to refine therapeutic strategies. Additionally, they will assess portfolio effectiveness, recommend actions, and facilitate brainstorming sessions. They serve as a key liaison between scientific teams, research enablement, translational medicine, early clinical development, external innovation, and cross-functional partners to maximize resource utilization and drive results. Roles and Responsibilities of the position: Lead operations of portfolio strategy, encompassing internal and external innovation. Organize and manage Immunology portfolio review meetings that occur on a bi-weekly and bi-annual cadence. Organize agendas, Teams/SharePoint sites, and communications with project teams, leadership, and stakeholders Ensure alignment and communication of strategic priorities with external partners Ensure project teams execute in alignment with discovery TPP and TA budget Collaborate with Immunology research and clinical leaders to develop and refine strategies for B, T, innate cell therapies, and special projects (e.g., incretins) Work closely with Discovery Leadership and project teams to define and update quarterly objectives and strategies. Support New Target Validation leader on process and operations for efficient assessment and decision-making for projects entering the portfolio. Facilitate brainstorming on project execution strategy and tactics, optimize project resourcing. Support External Innovation on development of research plans associated with collaborations Lead assessments of portfolio effectiveness and risk, recommend actions. Act as a key liaison between science teams, research enablement, translational medicine, bioinformatics, early clinical development, external innovation, and cross-functional partners to optimize resources and drive results for pre-/portfolio projects. Assist with preparations for portfolio updates and investor calls. Required Qualifications: BS, MS and/or PhD in immunology, molecular molecular biology, or relevant field Minimum 10 years of relevant experience (5 with PhD) in pharmaceutical and/or biotechnology companies Experience in creating and executing towards target product profiles for new therapeutic molecules with experience in at least two of the following autoimmune disease areas: dermatology (psoriasis, atopic dermatitis), rheumatology (rheumatoid arthritis, lupus), inflammatory bowel diseases (Crohn's disease, ulcerative colitis), and/or respiratory (asthma, COPD). Experience leading strategy workstreams. Able to elicit diverse opinions and work with teams and leadership to synthesize compelling strategies. Track-record of successful project conclusion Additional Preferences: Deep understanding of drug discovery and development in the area of immunology and autoimmunity, including competitive landscape, regulatory and commercial considerations Deep understanding of scientific principles underlying novel target discovery and factors affecting portfolio progression across therapeutic modalities, including but not limited to biologics, small molecules, and genetic medicines Expertise in T, B, or innate immune cell biology as demonstrated through publications. Experience in preclinical data package generation to support IND submissions Demonstrated success through publications and/or patents in discovering and developing hit to candidate stage molecules for autoimmune diseases across different modalities including experience with biologics, small molecules and antibody conjugates. Seasoned facilitator aligning people of diverse mindsets to achieve common ground Self-motivated individual who combines scientific curiosity and a passion for innovation with an enterprise mindset and a strong understanding of business concepts Exceptional attention to detail and critical thinking. Able to prioritize tasks and meet deadlines. Demonstrated ability to enhance team culture of innovation. Demonstrated ability to exhibit intellectual and strategic flexibility in a fast-paced environment. Impeccable organizational skills and attention to detail Exceptional written and verbal communication skills with technical and non-technical audiences. Ability to anticipate challenges and propose proactive solutions. Ability to empower teams and secure buy-in. Travel: Occasional travel may be required (less that 5 trips per year) Additional Information: Location: San Diego, Indianapolis, or Boston Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $166,500 - $268,400 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. WeAreLilly

Keywords: , Marthas Vineyard , Sr. Director - Immunology Portfolio Strategy and Operations, Science, Research & Development , Boston, Massachusetts