Senior Scientist Protein Chemistry

Company: Initial Therapeutics, Inc.
Location: Boston
Posted on: June 2, 2025

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionWe are seeking a highly skilled and motivated PhD level Protein Chemist to report into Takeda's Structural Biology organization. The ideal candidate will possess a strong background in the field of Protein Chemistry and/or Structural Biology and will use this expertise to produce and characterize proteins for structure determination by x-ray crystallography and cryo-EM as well as potential use in biochemical and biophysical assays to advance Takeda's drug discovery programs. A successful candidate will collaborate with external contract research organizations, internal protein production experts and multiple cross-functional project teams to plan and execute protein production requirements to progress Takeda's pipeline.The successful candidate will:

• Plan and execute protein production campaigns for structural biology efforts of small molecule and/or biologic complexes with target proteins in collaboration with structural biologists and protein chemists utilizing in-house protein production capabilities and contract research organizations, including utilization of in-house equipment and database resources.
• Analyze proprietary and public information to positively impact structure determination efforts, reagent or antigen protein production and characterization and/or antibody design, optimization and characterization.
• Work collaboratively and communicate clearly with interdisciplinary teams, including structural biologists, protein chemists, in vitro pharmacologists, medicinal and computational chemists, and project management to advance pipeline projects.
• Clearly communicate protein production and characterization plans, priorities, results and timelines to diverse audiences including structural biology group, project teams, department colleagues and senior leadership.Desired qualifications include:
  • PhD degree in a scientific discipline (Structural Biology, Biophysics, Biochemistry/Enzymology, Protein Chemistry) with 5+ years of protein production responsibilities in an industry setting; MS or BS candidates with suitable experience also considered.
  • Demonstrated track record of successful hands-on high-quality protein production (construct design, cloning, expression, purification, optimization, characterization) of protein reagents, antigens and/or antibodies or other biologics therapeutics for drug discovery teams.
  • Experience in protein production utilizing contract research organizations required, including efficient management of external resources, successful troubleshooting of challenging proteins, clear written and verbal communication and detailed documentation.
  • Success in design, expression and purification of membrane proteins and/or multi-protein complexes as well as extensive knowledge of and/or experience in structural biology methodologies, biochemical and/or biophysical assays highly desirable.
  • Passion for learning and advancing protein production capabilities and drug discovery pipelines, including proactive investigation of new techniques and capabilities, advanced software/hardware and innovative experimental approaches.
  • Ability to work collaboratively in a fast-paced, matrixed environment with a collaborative and proactive mindset, motivated by a desire to create therapeutic molecules for the benefit of patients in need worldwide.Takeda Compensation and Benefits SummaryWe understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.For Location:Boston, MAU.S. Base Salary Range:$133,000.00 - $209,000.00The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.U.S. based employees may be eligible for short-term and/or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull timeJob ExemptYesIt is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
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Keywords: Initial Therapeutics, Inc., Marthas Vineyard , Senior Scientist Protein Chemistry, Other , Boston, Massachusetts